Check4® Menopause

In women, the average hormonal cycle lasts 28 days. The FSH (Follicle Stimulating Hormone) secretion induces the follicle maturation, and LH (Luteinizing Hormone) secretion induces ovulation. The determination of FSH and LH level is indicated for the detection of amenorrhea and anovulatory cycles. Menopause arises at the mean age of 51 years old, i.e. between 45 and 55 years old depending on the individuals.

Menopause is caused by a significant change in the balance of hormones. An irregular menstrual cycle is often the first sign of menopause. Other signs like hot flushes, insomnia, palpitations, mouth ulcers, gingivitis, hair loss, vaginal dryness, osteoporosis, chills or excessive sweating could indicate menopause. The Check4® Menopause is a test for the determination of high levels of Follicle Stimulating Hormone in urine which is an indicator of menopause.

Check4® Menopause test uses a pair of antibodies for the specific detection of the human FSH. A control line capturing the excess of reagent appears in the control zone of the test. In case of positive result, it means that the FSH concentration is higher of 25 mIU/mL (as determined against W.H.O.* reference).

*World Health Organisation

The test can be used at any point of the menstrual cycle.

You can perform the test at any moment of the day. However, the first urine in the morning contains a large quantity of FSH.

The results are accurate only when the instructions for use are carefully followed. Nevertheless, the result can be incorrect if the Check4® Menopause test becomes damp before performing the test. Moreover, the Check4® Menopause test could be exceptionally distorted (i.e. a positive result for a young woman). In case of unexpected or contradictory results, it is recommended to consult a gynaecologist, as some health problems can give an incorrect diagnosis.

Yes. A few more seconds will not affect the results.

No, because the sample volume might be insufficient.

If the result is positive with the first Check4® Menopause test, a second test should be performed 5 or 7 days later. If a positive result is again obtained with a second test, the FSH level was elevated over an unusual period and could therefore indicate you are under experiencing menopause. You should consult your gynaecologist to confirm the diagnosis of menopause.

If the result is negative, the FSH level is lower than 25 mIU/mL which means you are probably not experiencing menopause. However, if you feel signs of menopause as indicated above, it is recommended to perform another test 40 to 60 days later or consult your gynaecologist.

No, the test has not been designed for this purpose and should not be used for this purpose.

If you use a contraceptive and have just discontinued using it, it is possible that your cycles may be irregular for some time, which may affect the result. It is recommended to wait for two cycles before using the Check4® Menopause tests.

A positive test indicates that the FSH level is equal or higher than 25 mIU/mL which means that you are possibly experiencing menopause. The menopause is defined as the cease of menstruation over a period of 12 months. However, this biological change in a woman’s life is gradual and is preceded by an earlier or later period which is named peri-menopause. So Therefore, the test result could be positive while your menstrual cycle duration is still regular. This means that you may be in the peri- menopause phase.

The Check4® Menopause test is very accurate and has been used for more than 10 years by professionals in the field. Evaluation reports show an overall agreement of 92.8% with reference method. Although this test is reliable, false positive or false negative results could still be obtained.

If you read the test before 10 minutes, you may not give the test enough time of work, and the test result may not be accurate. DO NOT INTERPRET the results if 15 minutes have elapsed after having brought the absorbent tip into contact with urine.